• 3-Methyladenine: Unlocking Novel Mechanisms in Autophagy ...

  2025-10-20

  Explore how 3-Methyladenine, a selective class III PI3K inhibitor, is redefining autophagy and ferroptosis research. Discover its dual inhibition mechanism and unique applications in cancer biology, offering translational insights beyond current literature.

• 3-Methyladenine: Precision Autophagy Inhibition for Advan...

  2025-10-19

  3-Methyladenine (3-MA) empowers translational researchers to dissect the intersections of autophagy, PI3K signaling, and novel cell death pathways such as cuproptosis. Its dual inhibition of class I and III PI3K provides unique experimental flexibility, enabling high-resolution mechanistic studies in oncology and cell migration.

• Expanding the Translational Horizon: 3-Methyladenine as a...

  2025-10-18

  This thought-leadership article provides a strategic, mechanistic, and translational roadmap for researchers exploring autophagy inhibition, PI3K signaling, and novel cell death pathways in cancer. By leveraging 3-Methyladenine’s unique dual inhibition of class III and class I PI3K, we illuminate new opportunities for experimental innovation, especially at the intersection of autophagy, cuproptosis, and ferroptosis resistance. Drawing on recent advances—including the rational design of copper ionophores to induce cuproptosis—we offer actionable guidance, competitive analysis, and a forward-looking vision for translational oncology.

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